Title

Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP): An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies

Authors

Moses Lee

ACS Citation

Lee, M. Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP): An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies. J. Chem. Educ. 1996, 73, 184-184.

Abstract

The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees. The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees.

Source Name

Journal of Chemical Education

Publication Date

1-1-1996

Volume

73

Issue

2

Page(s)

363-363

Document Type

Citation

Citation Type

Article