Synthesis of cis-[Cr(diimine)2(1-methylimidazole)2]3+ Complexes and an Investigation of Their Interaction with Mononucleotides and Polynucleotides
Goforth, S.K.; Gill, T.W.; Weisbruch, A.E.; Kane-Maguire, K.A.; Helsel, M.E.; Sun, K.W.; Rodgers, H.D.; Stanley, F.E.; Goudy, S.R.; Wheeler, S.K.; Wheeler, J.F.; Kane-Maguire, N.A.P. Synthesis of cis-[Cr(diimine)2(1-methylimidazole)2]3+ Complexes and an Investigation of Their Interaction with Mononucleotides and Polynucleotides. Inorg. Chem., 2016, 55(4), 1516–1526.
A protocol is presented for the synthesis of chromium(III) complexes of the type cis-[Cr(diimine)2(1-methylimidazole)2]3+. These compounds exhibit large excited- state oxidizing powers and strong luminescence in solution.Emission is quenched by added guanine, yielding rate constants that track the driving force for guanine oxidation. The cis-[Cr(TMP)(DPPZ)(1-MeImid)2]3+species binds strongly to duplex DNA with a preference for AT base sites in the minor groove and may serve as a precursor for photo activated DNA covalent adduct formation.