Computational approaches for the design of peptides with anti-breast cancer properties
ACS Citation
Shields, G. C. Computational Approaches for the Design of Peptides with Anti-Breast Cancer Properties. Future Med. Chem. 2009, 1 (1), 201-212.
Version of Record
Abstract
Background: Breast cancer is the most common cancer among women. Tamoxifen is the preferred drug for estrogen receptor-positive breast cancer treatment, yet many of these cancers are intrinsically resistant to tamoxifen or acquire resistance during treatment. Therefore, scientists are searching for breast cancer drugs that have different molecular targets. Methodology: Recently, a computational approach was used to successfully design peptides that are new lead compounds against breast cancer. We used replica exchange molecular dynamics to predict the structure and dynamics of active peptides, leading to the discovery of smaller bioactive peptides. Conclusions: These analogs inhibit estrogen-dependent cell growth in a mouse uterine growth assay, a test showing reliable correlation with human breast cancer inhibition. We outline the computational methods that were tried and used along with the experimental information that led to the successful completion of this research.
Source Name
Future Medicinal Chemistry
Publication Date
2009
Volume
1
Issue
1
Page(s)
201-212
Document Type
Citation
Citation Type
Article