Title

The effect of the amount of celecoxib administered on the number of cases of atrial fibrillation in four groups of Daphnia magna

Author(s)

Jackson B. Hall

School Name

Spring Valley High School

Grade Level

11th Grade

Presentation Topic

Physiology and Health

Presentation Type

Non-Mentored

Abstract

This study was trying to determine if the amount of celecoxib administered affected the number of cases of atrial fibrillation in four populations of Daphnia magna. The hypothesis was that if four groups of Daphnia magna are exposed to celecoxib dosages of either 0 mg, 200 mg, 400 mg, or 600 mg, then there will be more Daphnia magna from the group exposed to the equivalent 600 mg dosage that develop atrial fibrillation. During the experiment, different groups of Daphnia magna were given a different dosage of medicine. After a certain amount of time, each Daphnia magna was examined to see if atrial fibrillation had developed. A chi-square test for independence was performed to determine if the rates of alive and dead Daphnia magna were dependent on the celecoxib dosage. Based on the chi-square test for independence, the null hypothesis that the rates of alive and dead Daphnia magna were independent of celecoxib dosage was rejected, X2 (3, N = 67) = 16.77, p < 0.001. By rejecting the null hypothesis, it meant that the rates of dead and alive Daphnia magna depended on the dosage administered. Statistical analysis was not used to determine if the atrial fibrillation rates were dependent on the celecoxib dosages because it was believed that no significance would be shown due to the low incidence rate of atrial fibrillation. Just using the raw data, the original hypothesis that the greatest number of diagnosed atrial fibrillation cases would come from the 600 mg dosage group should be refuted.

Start Date

4-11-2015 11:00 AM

End Date

4-11-2015 11:15 AM

COinS
 
Apr 11th, 11:00 AM Apr 11th, 11:15 AM

The effect of the amount of celecoxib administered on the number of cases of atrial fibrillation in four groups of Daphnia magna

This study was trying to determine if the amount of celecoxib administered affected the number of cases of atrial fibrillation in four populations of Daphnia magna. The hypothesis was that if four groups of Daphnia magna are exposed to celecoxib dosages of either 0 mg, 200 mg, 400 mg, or 600 mg, then there will be more Daphnia magna from the group exposed to the equivalent 600 mg dosage that develop atrial fibrillation. During the experiment, different groups of Daphnia magna were given a different dosage of medicine. After a certain amount of time, each Daphnia magna was examined to see if atrial fibrillation had developed. A chi-square test for independence was performed to determine if the rates of alive and dead Daphnia magna were dependent on the celecoxib dosage. Based on the chi-square test for independence, the null hypothesis that the rates of alive and dead Daphnia magna were independent of celecoxib dosage was rejected, X2 (3, N = 67) = 16.77, p < 0.001. By rejecting the null hypothesis, it meant that the rates of dead and alive Daphnia magna depended on the dosage administered. Statistical analysis was not used to determine if the atrial fibrillation rates were dependent on the celecoxib dosages because it was believed that no significance would be shown due to the low incidence rate of atrial fibrillation. Just using the raw data, the original hypothesis that the greatest number of diagnosed atrial fibrillation cases would come from the 600 mg dosage group should be refuted.