Title

Design And Synthesis Of A Novel Lsd-1 Inhibitor As A Potential Anti-Tumor Agent

Author(s)

Frances Davenport

School Name

Governor's School for Science and Math

Grade Level

12th Grade

Presentation Topic

Biochemistry

Presentation Type

Mentored

Mentor

Mentor: Dr. Woster; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina

Oral Presentation Award

2nd Place

Abstract

Compound C1 successfully occupies the enzyme pocket of Lysine-specific demethylase (LSD1) and prevents the demethylation of histone tails. Histone demethylase causes tumor suppressor genes to be turned off. For this reason, LSD1 inhibitors show potential as antitumor agents. Many of the currently known LSD1 inhibitors are poor drug candidates. The purpose of this study was to create a derivative of a known LSD1 inhibitor that is both more active than the original and soluble in water. These properties will allow the compound to be used for tumor-suppressing drugs.

Location

Owens 203

Start Date

4-16-2016 9:45 AM

COinS
 
Apr 16th, 9:45 AM

Design And Synthesis Of A Novel Lsd-1 Inhibitor As A Potential Anti-Tumor Agent

Owens 203

Compound C1 successfully occupies the enzyme pocket of Lysine-specific demethylase (LSD1) and prevents the demethylation of histone tails. Histone demethylase causes tumor suppressor genes to be turned off. For this reason, LSD1 inhibitors show potential as antitumor agents. Many of the currently known LSD1 inhibitors are poor drug candidates. The purpose of this study was to create a derivative of a known LSD1 inhibitor that is both more active than the original and soluble in water. These properties will allow the compound to be used for tumor-suppressing drugs.