Fibromodulin (Fomd) And Lumican (Lum) In Adult Mouse Cardiac Valve Development

Ashton Lancaster

School Name

Governor's School for Science and Math

Grade Level

12th Grade

Presentation Topic

Physiology and Health

Presentation Type

Mentored

Mentor

Mentor: Dr. Kern; Department of Regenerative Medicine, Medical University of South Carolina

Abstract

Cardiac valve disease is widespread, yet uncured. The Small Leucine Rich Proteoglycans Fibromodulin (fomd) and Lumican (lum), found in the Extracellular Matrix, are expressed in developing cardiac valves. Previous studies have shown that lum promotes the development of the valves, but not much research has been done on the role of fomd. To determine their impact on valve development and disease, the right and left coronary cusps of the aortic valve were compared between knock out and wild type mice. Mice deficient in both fomd and lum were found to have smaller distal portions of the left and right cusps in their aortic valves than their wild type counterparts. Fomd and lum were both found to play a role in aortic valve development, which was previously undetermined. This information could be used to develop drugs to treat cardiac valve disease.

Location

Owens 107

Start Date

4-16-2016 9:00 AM

COinS
 
Apr 16th, 9:00 AM

Fibromodulin (Fomd) And Lumican (Lum) In Adult Mouse Cardiac Valve Development

Owens 107

Cardiac valve disease is widespread, yet uncured. The Small Leucine Rich Proteoglycans Fibromodulin (fomd) and Lumican (lum), found in the Extracellular Matrix, are expressed in developing cardiac valves. Previous studies have shown that lum promotes the development of the valves, but not much research has been done on the role of fomd. To determine their impact on valve development and disease, the right and left coronary cusps of the aortic valve were compared between knock out and wild type mice. Mice deficient in both fomd and lum were found to have smaller distal portions of the left and right cusps in their aortic valves than their wild type counterparts. Fomd and lum were both found to play a role in aortic valve development, which was previously undetermined. This information could be used to develop drugs to treat cardiac valve disease.