Title

The Effect Of The Inhibitory Effects Of Benfotiamine, L Ascorbic Acid, And A Lipoic Acid On The Production Of Advanced Glycation End Products In Caenorhabditis Elegans /

Author(s)

Vinay Penmetsa

School Name

Spring Valley High School

Grade Level

11th Grade

Presentation Topic

Microbiology

Presentation Type

Non-Mentored

Written Paper Award

1st Place

Abstract

The average human lifespan is around 71 years of age, with females living slightly longer than males. As humans grow older, the homeostatic processes in the body progressively becomes less and less effective, which leaves the body vulnerable to many diseases. One of the contributing factors to growing older is advanced glycation end products, otherwise known as AGEs. This experiment gives Benfotiamine, A-Lipoic acid, and L-Ascorbic acid, which have been proven to be effective at reducing the production of AGEs, to Caenorhabditis elegans to see if it increases their lifespan. The lifespan of the C. elegans was counted over a three week period, and was counted daily. The hypothesis of giving drugs to C. elegans increasing their lifespan was proven to be supported. At an alpha level of 0.05, the three drugs had a significantly different lifespan than the control, F(3, 354)=15.68, p<0.05, supported by a Tukey test.. Comparing the drugs to each other, L-Ascorbic acid had the highest average lifespan, with Benfotiamine and A-Lipoic acid having similar results. The control group had the lowest lifespan, with almost a one day difference between it and the lowest drug. In conclusion, the drugs did have a significant effect on the lifespan of the C. elegans and it can be suggested that it is because of their effect on the production of AGEs in the C. elegans. / /

Location

Owens 110

Start Date

4-16-2016 10:45 AM

COinS
 
Apr 16th, 10:45 AM

The Effect Of The Inhibitory Effects Of Benfotiamine, L Ascorbic Acid, And A Lipoic Acid On The Production Of Advanced Glycation End Products In Caenorhabditis Elegans /

Owens 110

The average human lifespan is around 71 years of age, with females living slightly longer than males. As humans grow older, the homeostatic processes in the body progressively becomes less and less effective, which leaves the body vulnerable to many diseases. One of the contributing factors to growing older is advanced glycation end products, otherwise known as AGEs. This experiment gives Benfotiamine, A-Lipoic acid, and L-Ascorbic acid, which have been proven to be effective at reducing the production of AGEs, to Caenorhabditis elegans to see if it increases their lifespan. The lifespan of the C. elegans was counted over a three week period, and was counted daily. The hypothesis of giving drugs to C. elegans increasing their lifespan was proven to be supported. At an alpha level of 0.05, the three drugs had a significantly different lifespan than the control, F(3, 354)=15.68, p<0.05, supported by a Tukey test.. Comparing the drugs to each other, L-Ascorbic acid had the highest average lifespan, with Benfotiamine and A-Lipoic acid having similar results. The control group had the lowest lifespan, with almost a one day difference between it and the lowest drug. In conclusion, the drugs did have a significant effect on the lifespan of the C. elegans and it can be suggested that it is because of their effect on the production of AGEs in the C. elegans. / /