The Effect of Histone Methylation on Noise Induced Hearing Loss

School Name

Governor's School for Science & Mathematics

Grade Level

12th Grade

Presentation Topic

Physiology and Health

Presentation Type

Mentored

Mentor

Mentor: Su-Hua Sha, Medical University of South Carolina

Oral Presentation Award

3rd Place

Written Paper Award

2nd Place

Abstract

The mechanism for noise induced hearing loss is currently unknown thus, it is not known how to prevent or treat it. Mice treated with BIX-01294, a pharmacological inhibitor, were compared with control mice after both groups were exposed to damaging levels of noise. The differences in outer hair cell damage and hearing loss were evaluated. The mice treated with BIX-01294, which inhibits histone methylation, exhibited less methylation than the control mice, indicating that the inhibitor worked as predicted. The BIX-01294 treated mice also exhibited fewer signs of noise induced hearing loss and had significantly less outer hair cell loss. This suggests that the inhibition of methylation could be used as a method to prevent noise induced hearing loss.

Location

Wall 318

Start Date

3-25-2017 1:30 PM

Presentation Format

Oral and Written

Group Project

No

COinS
 
Mar 25th, 1:30 PM

The Effect of Histone Methylation on Noise Induced Hearing Loss

Wall 318

The mechanism for noise induced hearing loss is currently unknown thus, it is not known how to prevent or treat it. Mice treated with BIX-01294, a pharmacological inhibitor, were compared with control mice after both groups were exposed to damaging levels of noise. The differences in outer hair cell damage and hearing loss were evaluated. The mice treated with BIX-01294, which inhibits histone methylation, exhibited less methylation than the control mice, indicating that the inhibitor worked as predicted. The BIX-01294 treated mice also exhibited fewer signs of noise induced hearing loss and had significantly less outer hair cell loss. This suggests that the inhibition of methylation could be used as a method to prevent noise induced hearing loss.