Transition-Metal-Catalyzed Regeneration of Nicotinamide Coenzymes with Hydrogen¹

Authors

Paul S. Wagenknecht, Furman UniversityFollow
Jonathan M. Penney
Robert T. Hembre

ACS Citation

Wagenknecht, P. S.; Penney, J. M.; Hembre, R. T. Transition-Metal-Catalyzed Regeneration of Nicotinamide Coenzymes with Hydrogen¹. Organometallics 2003, 22, 1180-1182.

Version of Record

10.1021/om020843u

Abstract

The nicotinamide coenzymes consumed in alcohol dehydrogenase catalyzed enantioselective reduction of ketones are expensive and thus require recycling. We have demonstrated that ruthenium(II) and rhodium(III) complexes are effective catalysts for the reduction of nicotinamide coenzymes with hydrogen, under conditions that are appropriate for in situ coupling with enzymatic reductions. The nicotinamide coenzymes consumed in alcohol dehydrogenase catalyzed enantioselective reduction of ketones are expensive and thus require recycling. We have demonstrated that ruthenium(II) and rhodium(III) complexes are effective catalysts for the reduction of nicotinamide coenzymes with hydrogen, under conditions that are appropriate for in situ coupling with enzymatic reductions.

Source Name

Organometallics

Publication Date

1-1-2003

Volume

22

Issue

6

Page(s)

4587-4587

Document Type

Citation

Citation Type

Article