Title

Synthesis and Potent Antimalarial Activity of Kalihinol B.

ACS Citation

Daub, M. E.; Prudhomme, J.; Le Roch, K.; Vanderwal, C. D. Synthesis and Potent Antimalarial Activity of Kalihinol B. J. Am. Chem. Soc. 2015, 137, 4912–4915.

Abstract

Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to access many of the kalihinanes with a 12-step enantioselective synthesis of kalihinol B, the tetrahydrofuran isomer of kalihinol A (a tetrahydropyran). Kalihinol B shows similarly high potency against chloroquine-resistant Plasmodium falciparum.

Source Name

Journal of the American Chemical Society

Publication Date

3-27-2015

Volume

137

Issue

15

Page(s)

4912-4915

Document Type

Article

Citation Type

Article

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