Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

Kortney M. Kersten
Meghan E. Breen
Anna K. Mapp
Adam J. Matzger


Antimicrobial functionality is introduced into a pharmaceutical formulation of miconazole while improving solubility. The work leverages hydrate formation propensity in order to produce hydrogen peroxide solvates. The ubiquity of hydrate formation suggests that hydrogen peroxide can be broadly deployed in pharmaceuticals, rendering a liquid excipient suitable for solid pharmaceutical formulations.