Title

N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides

ACS Citation

Fayer, E.L.; Gilliland Jr, W.M.; Ramsey, J.M.; Allbritton, N.L.; Waters, M.L. N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides. Chem. Commun. 2018, 54, 204-207.

Abstract

Herein we describe a synthetically simple strategy for increasing the lifetime of unstructured peptides in cytosolic environment via dimerization at the N-terminus to block threading into the catalytic cleft of cytosolic proteases. We establish this approach with kinase substrates, allowing for phosphorylation in cells as a demonstration of protease resistance.

Source Name

Chemical Communications

Publication Date

12-12-2017

Issue

2

Page(s)

204-207

Document Type

Citation

Citation Type

Article

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