A Plausible Prebiotic One-Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways
Clay, A.P.; Cooke, R.E.; Kumar, R.; Yadav, M.; Krishnamurthy, R.; Springsteen, G. "A Plausible Prebiotic One‐Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways", Angewandte Chem Int. Ed., 2022, 61, 11.
A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co-evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment. Additionally, open-chain thiohydantoin derivatives enable a synthesis of thioorotate nucleosides.
Angewandte Chemie. International Edition