Title

The Formulation of Budesonide Inhalation Solution

School Name

Governor's School for Science and Mathematics

Grade Level

12th Grade

Presentation Topic

Biochemistry

Presentation Type

Mentored

Abstract

Budesonide is a corticosteroid that treats the symptoms of asthma to allow for easier breathing. There is not currently a solution formulation of budesonide for the purposes of inhalation due to the molecule’s hydrophobicity. In this research, we used a nanoparticle-based surfactant solubilizer to aid the dissolution of the budesonide molecule. Over a period of six weeks, we formulated three budesonide solutions, each with a different mixing time. With the goal of creating the most stable budesonide solution we tested and compared these formulations. Using a sixty-degree Celsius oven and a forty-degree Celsius accelerated chamber, we conducted a stability study to accelerate the testing of the longevity of the solutions. A High Performance Liquid Chromatography machine was used to test the solutions for purity and measure the amount of active pharmaceutical ingredient that remained in solution. At the end of the stability study, the ninety-minute mix formulation was the most stable. Because of the inconsistencies in the collected data, this experiment brings forth no concrete conclusions.

Location

Neville 106

Start Date

4-14-2018 8:30 AM

Presentation Format

Oral and Written

COinS
 
Apr 14th, 8:30 AM

The Formulation of Budesonide Inhalation Solution

Neville 106

Budesonide is a corticosteroid that treats the symptoms of asthma to allow for easier breathing. There is not currently a solution formulation of budesonide for the purposes of inhalation due to the molecule’s hydrophobicity. In this research, we used a nanoparticle-based surfactant solubilizer to aid the dissolution of the budesonide molecule. Over a period of six weeks, we formulated three budesonide solutions, each with a different mixing time. With the goal of creating the most stable budesonide solution we tested and compared these formulations. Using a sixty-degree Celsius oven and a forty-degree Celsius accelerated chamber, we conducted a stability study to accelerate the testing of the longevity of the solutions. A High Performance Liquid Chromatography machine was used to test the solutions for purity and measure the amount of active pharmaceutical ingredient that remained in solution. At the end of the stability study, the ninety-minute mix formulation was the most stable. Because of the inconsistencies in the collected data, this experiment brings forth no concrete conclusions.