The Formulation of Budesonide Inhalation Solution
School Name
Governor's School for Science and Mathematics
Grade Level
12th Grade
Presentation Topic
Biochemistry
Presentation Type
Mentored
Abstract
Budesonide is a corticosteroid that treats the symptoms of asthma to allow for easier breathing. There is not currently a solution formulation of budesonide for the purposes of inhalation due to the molecule’s hydrophobicity. In this research, we used a nanoparticle-based surfactant solubilizer to aid the dissolution of the budesonide molecule. Over a period of six weeks, we formulated three budesonide solutions, each with a different mixing time. With the goal of creating the most stable budesonide solution we tested and compared these formulations. Using a sixty-degree Celsius oven and a forty-degree Celsius accelerated chamber, we conducted a stability study to accelerate the testing of the longevity of the solutions. A High Performance Liquid Chromatography machine was used to test the solutions for purity and measure the amount of active pharmaceutical ingredient that remained in solution. At the end of the stability study, the ninety-minute mix formulation was the most stable. Because of the inconsistencies in the collected data, this experiment brings forth no concrete conclusions.
Recommended Citation
Free, Olivia and Coghlan, Kaitlyn, "The Formulation of Budesonide Inhalation Solution" (2018). South Carolina Junior Academy of Science. 1.
https://scholarexchange.furman.edu/scjas/2018/all/1
Location
Neville 106
Start Date
4-14-2018 8:30 AM
Presentation Format
Oral and Written
The Formulation of Budesonide Inhalation Solution
Neville 106
Budesonide is a corticosteroid that treats the symptoms of asthma to allow for easier breathing. There is not currently a solution formulation of budesonide for the purposes of inhalation due to the molecule’s hydrophobicity. In this research, we used a nanoparticle-based surfactant solubilizer to aid the dissolution of the budesonide molecule. Over a period of six weeks, we formulated three budesonide solutions, each with a different mixing time. With the goal of creating the most stable budesonide solution we tested and compared these formulations. Using a sixty-degree Celsius oven and a forty-degree Celsius accelerated chamber, we conducted a stability study to accelerate the testing of the longevity of the solutions. A High Performance Liquid Chromatography machine was used to test the solutions for purity and measure the amount of active pharmaceutical ingredient that remained in solution. At the end of the stability study, the ninety-minute mix formulation was the most stable. Because of the inconsistencies in the collected data, this experiment brings forth no concrete conclusions.
