Augumenting Anti- Cancer Therapy Using the Immune System and Cytokines
School Name
Governor's School for Science and Mathematics
Grade Level
12th Grade
Presentation Topic
Cell and Molecular Biology
Presentation Type
Mentored
Abstract
Lung cancer is one of the most common cancer types, yet many of the most ground-breaking cancer immunology therapies are ineffective. Determining proper cytokine dosages to stimulate proliferation is vital to furthering efficacy of lung cancer immunology research. Refining the efficacy of T Cell proliferation advances cancer immunotherapy for melanoma patients. Based on prior research, IL-2 and IL-15 are similar stimulants that activate T cells. They prove to be equally effective, except IL-2 stimulated cells are bigger and show more growth. In lab, mouse spleen cells underwent a CD3 stimulation to observe the difference between IL-2 stimulated cells and IL-15 stimulated cell and to determine which interleukin concentration is most effective and least toxic to cells IL-15 stimulated cells and IL-2 stimulated cells both showed similar results. They both proliferated at about the same rate at about the same dosages. It was concluded, IL-2 induce proliferation in activated T Cells, but do not induce proliferation in naïve T Cells. IL-2 and IL-15 both prove to be able to best induce proliferation of T cells at similar dosages.
Recommended Citation
Emetu, Faith, "Augumenting Anti- Cancer Therapy Using the Immune System and Cytokines" (2018). South Carolina Junior Academy of Science. 18.
https://scholarexchange.furman.edu/scjas/2018/all/18
Location
Neville theater
Start Date
4-14-2018 8:45 AM
Presentation Format
Oral and Written
Augumenting Anti- Cancer Therapy Using the Immune System and Cytokines
Neville theater
Lung cancer is one of the most common cancer types, yet many of the most ground-breaking cancer immunology therapies are ineffective. Determining proper cytokine dosages to stimulate proliferation is vital to furthering efficacy of lung cancer immunology research. Refining the efficacy of T Cell proliferation advances cancer immunotherapy for melanoma patients. Based on prior research, IL-2 and IL-15 are similar stimulants that activate T cells. They prove to be equally effective, except IL-2 stimulated cells are bigger and show more growth. In lab, mouse spleen cells underwent a CD3 stimulation to observe the difference between IL-2 stimulated cells and IL-15 stimulated cell and to determine which interleukin concentration is most effective and least toxic to cells IL-15 stimulated cells and IL-2 stimulated cells both showed similar results. They both proliferated at about the same rate at about the same dosages. It was concluded, IL-2 induce proliferation in activated T Cells, but do not induce proliferation in naïve T Cells. IL-2 and IL-15 both prove to be able to best induce proliferation of T cells at similar dosages.
