Title

Augumenting Anti- Cancer Therapy Using the Immune System and Cytokines

Author(s)

Faith Emetu, GSSM

School Name

Governor's School for Science and Mathematics

Grade Level

12th Grade

Presentation Topic

Cell and Molecular Biology

Presentation Type

Mentored

Abstract

Lung cancer is one of the most common cancer types, yet many of the most ground-breaking cancer immunology therapies are ineffective. Determining proper cytokine dosages to stimulate proliferation is vital to furthering efficacy of lung cancer immunology research. Refining the efficacy of T Cell proliferation advances cancer immunotherapy for melanoma patients. Based on prior research, IL-2 and IL-15 are similar stimulants that activate T cells. They prove to be equally effective, except IL-2 stimulated cells are bigger and show more growth. In lab, mouse spleen cells underwent a CD3 stimulation to observe the difference between IL-2 stimulated cells and IL-15 stimulated cell and to determine which interleukin concentration is most effective and least toxic to cells IL-15 stimulated cells and IL-2 stimulated cells both showed similar results. They both proliferated at about the same rate at about the same dosages. It was concluded, IL-2 induce proliferation in activated T Cells, but do not induce proliferation in naïve T Cells. IL-2 and IL-15 both prove to be able to best induce proliferation of T cells at similar dosages.

Location

Neville theater

Start Date

4-14-2018 8:45 AM

Presentation Format

Oral and Written

COinS
 
Apr 14th, 8:45 AM

Augumenting Anti- Cancer Therapy Using the Immune System and Cytokines

Neville theater

Lung cancer is one of the most common cancer types, yet many of the most ground-breaking cancer immunology therapies are ineffective. Determining proper cytokine dosages to stimulate proliferation is vital to furthering efficacy of lung cancer immunology research. Refining the efficacy of T Cell proliferation advances cancer immunotherapy for melanoma patients. Based on prior research, IL-2 and IL-15 are similar stimulants that activate T cells. They prove to be equally effective, except IL-2 stimulated cells are bigger and show more growth. In lab, mouse spleen cells underwent a CD3 stimulation to observe the difference between IL-2 stimulated cells and IL-15 stimulated cell and to determine which interleukin concentration is most effective and least toxic to cells IL-15 stimulated cells and IL-2 stimulated cells both showed similar results. They both proliferated at about the same rate at about the same dosages. It was concluded, IL-2 induce proliferation in activated T Cells, but do not induce proliferation in naïve T Cells. IL-2 and IL-15 both prove to be able to best induce proliferation of T cells at similar dosages.