Title

KDM4B Inhibition to Help Cure Periodontal Disease

School Name

Governor's School for Science and Mathematics

Grade Level

12th Grade

Presentation Topic

Biochemistry

Presentation Type

Mentored

Abstract

Periodontal disease is an oral inflammatory disease that affects much of the American population and currently has no cure. The inflammatory response is controlled by the coordinated genes, KDM4B and KDM1A. KDM4B causes inflammation while KDM1A suppresses it. Therefore, a reduction in KDM4B expression and an increase in KDM1A expression would lower inflammation. Previous research has shown that ML324 is a probable candidate for treating periodontal disease through inhibition of KDM4B. During this research derivatives of Drug 8, a drug targeted to inhibit KDM4B, were synthesized. We tested ML324 along with Drug 8 and its two derivatives on cell cultures. The inflammatory response was measured and compared. Our results show that ML324 continues to be a promising candidate, Drug 8 suppressed the inflammatory response to a lesser degree, and the two derivatives of Drug 8 did not suppress any inflammation.

Location

Neville 106

Start Date

4-14-2018 10:15 AM

Presentation Format

Oral and Written

COinS
 
Apr 14th, 10:15 AM

KDM4B Inhibition to Help Cure Periodontal Disease

Neville 106

Periodontal disease is an oral inflammatory disease that affects much of the American population and currently has no cure. The inflammatory response is controlled by the coordinated genes, KDM4B and KDM1A. KDM4B causes inflammation while KDM1A suppresses it. Therefore, a reduction in KDM4B expression and an increase in KDM1A expression would lower inflammation. Previous research has shown that ML324 is a probable candidate for treating periodontal disease through inhibition of KDM4B. During this research derivatives of Drug 8, a drug targeted to inhibit KDM4B, were synthesized. We tested ML324 along with Drug 8 and its two derivatives on cell cultures. The inflammatory response was measured and compared. Our results show that ML324 continues to be a promising candidate, Drug 8 suppressed the inflammatory response to a lesser degree, and the two derivatives of Drug 8 did not suppress any inflammation.