Title

The Potential Efficacy of Targeted Gold Nanoparticles In the Micro-CT Imaging of LN229 Human Glioblastoma Cells

School Name

South Carolina Governor's School for Science & Mathematics

Grade Level

12th Grade

Presentation Topic

Cell and Molecular Biology

Presentation Type

Mentored

Abstract

Human glioblastoma multiforme (GBM) is one of the most aggressive and lethal forms of brain cancer, with a patient survival rate of only 12 months post-diagnosis. Detection of GBM in humans is a challenge due the location and histopathology of the tumor and imaging is also a difficulty for the same reasons. Imaging GBM tumors using computer tomography (CT) is low cost and highly accessible, but samples must reach a minimum target density in order to be visible on the scan. Potentially, however, these challenges can be overcome utilizing AuNPs as a contrast agent. The aim of this research is to gauge the plausibility of using AuNPs as a contrast agent in LN229 GBM cells and using the available data on AuNPs and data collected from a 2D microscopic image of an LN229 sample. Although the research done was very preliminary, the calculations indicate that from a mathematical standpoint, achieving target density via AuNPs is more than possible.

Location

Founders Hall 114 A

Start Date

3-30-2019 8:45 AM

Presentation Format

Oral Only

Group Project

No

COinS
 
Mar 30th, 8:45 AM

The Potential Efficacy of Targeted Gold Nanoparticles In the Micro-CT Imaging of LN229 Human Glioblastoma Cells

Founders Hall 114 A

Human glioblastoma multiforme (GBM) is one of the most aggressive and lethal forms of brain cancer, with a patient survival rate of only 12 months post-diagnosis. Detection of GBM in humans is a challenge due the location and histopathology of the tumor and imaging is also a difficulty for the same reasons. Imaging GBM tumors using computer tomography (CT) is low cost and highly accessible, but samples must reach a minimum target density in order to be visible on the scan. Potentially, however, these challenges can be overcome utilizing AuNPs as a contrast agent. The aim of this research is to gauge the plausibility of using AuNPs as a contrast agent in LN229 GBM cells and using the available data on AuNPs and data collected from a 2D microscopic image of an LN229 sample. Although the research done was very preliminary, the calculations indicate that from a mathematical standpoint, achieving target density via AuNPs is more than possible.