The Potential Efficacy of Targeted Gold Nanoparticles In the Micro-CT Imaging of LN229 Human Glioblastoma Cells
School Name
South Carolina Governor's School for Science & Mathematics
Grade Level
12th Grade
Presentation Topic
Cell and Molecular Biology
Presentation Type
Mentored
Abstract
Human glioblastoma multiforme (GBM) is one of the most aggressive and lethal forms of brain cancer, with a patient survival rate of only 12 months post-diagnosis. Detection of GBM in humans is a challenge due the location and histopathology of the tumor and imaging is also a difficulty for the same reasons. Imaging GBM tumors using computer tomography (CT) is low cost and highly accessible, but samples must reach a minimum target density in order to be visible on the scan. Potentially, however, these challenges can be overcome utilizing AuNPs as a contrast agent. The aim of this research is to gauge the plausibility of using AuNPs as a contrast agent in LN229 GBM cells and using the available data on AuNPs and data collected from a 2D microscopic image of an LN229 sample. Although the research done was very preliminary, the calculations indicate that from a mathematical standpoint, achieving target density via AuNPs is more than possible.
Recommended Citation
Eisenhart, Rachel, "The Potential Efficacy of Targeted Gold Nanoparticles In the Micro-CT Imaging of LN229 Human Glioblastoma Cells" (2019). South Carolina Junior Academy of Science. 281.
https://scholarexchange.furman.edu/scjas/2019/all/281
Location
Founders Hall 114 A
Start Date
3-30-2019 8:45 AM
Presentation Format
Oral Only
Group Project
No
The Potential Efficacy of Targeted Gold Nanoparticles In the Micro-CT Imaging of LN229 Human Glioblastoma Cells
Founders Hall 114 A
Human glioblastoma multiforme (GBM) is one of the most aggressive and lethal forms of brain cancer, with a patient survival rate of only 12 months post-diagnosis. Detection of GBM in humans is a challenge due the location and histopathology of the tumor and imaging is also a difficulty for the same reasons. Imaging GBM tumors using computer tomography (CT) is low cost and highly accessible, but samples must reach a minimum target density in order to be visible on the scan. Potentially, however, these challenges can be overcome utilizing AuNPs as a contrast agent. The aim of this research is to gauge the plausibility of using AuNPs as a contrast agent in LN229 GBM cells and using the available data on AuNPs and data collected from a 2D microscopic image of an LN229 sample. Although the research done was very preliminary, the calculations indicate that from a mathematical standpoint, achieving target density via AuNPs is more than possible.
