Conceptualization of Lact In Conjunction With EGCG for Cell-Targeting Apoptosis Within C. Elegans Utilized As A Rapidly Proliferating Cancer Model for Tumorigenesis Prevention/Suppression

School Name

Spring Valley High School

Grade Level

11th Grade

Presentation Topic

Microbiology

Presentation Type

Non-Mentored

Abstract

Approximately 1 in every 4 deaths in the United States are due to cancer. In accordance with the vast negatives present with the diagnosis of cancer, financial issues arise as well. In fact, some estimate basic chemotherapy to be as high as $65,000 over a month long period. Recent studies have introduced LACT within malarial prophylaxis to be used in a synergistic combination with cancer. Since both artemisinin and EGCG have anticancer and cell-targeting properties, their use may prove beneficial in the prevention/treatment of cancer. This project focuses on such anticarcinogenic and antiproliferative characteristics: specifically the synergy between these two drugs and how they could allow cell-targeting of artemisinin to stay intact while LACT driven functions of EGCG are still effective. These characteristics have been seen in the previous study utilizing an MIC concentration. This previously established synergistic MIC is used on C. elegans, which are dyed using a DAPI fluorescence assay and tested at specified wavelengths to assess apoptotic and nonviable cells. The combination would introduce a cost-effective treatment which may induce more apoptosis than current chemotherapy, thus decreasing the typical hardships in cancer treatment today. After experimentation, it was shown that because t(14)=1.7613, p

Location

Founders Hall 216 B

Start Date

3-30-2019 11:15 AM

Presentation Format

Oral and Written

Group Project

No

COinS
 
Mar 30th, 11:15 AM

Conceptualization of Lact In Conjunction With EGCG for Cell-Targeting Apoptosis Within C. Elegans Utilized As A Rapidly Proliferating Cancer Model for Tumorigenesis Prevention/Suppression

Founders Hall 216 B

Approximately 1 in every 4 deaths in the United States are due to cancer. In accordance with the vast negatives present with the diagnosis of cancer, financial issues arise as well. In fact, some estimate basic chemotherapy to be as high as $65,000 over a month long period. Recent studies have introduced LACT within malarial prophylaxis to be used in a synergistic combination with cancer. Since both artemisinin and EGCG have anticancer and cell-targeting properties, their use may prove beneficial in the prevention/treatment of cancer. This project focuses on such anticarcinogenic and antiproliferative characteristics: specifically the synergy between these two drugs and how they could allow cell-targeting of artemisinin to stay intact while LACT driven functions of EGCG are still effective. These characteristics have been seen in the previous study utilizing an MIC concentration. This previously established synergistic MIC is used on C. elegans, which are dyed using a DAPI fluorescence assay and tested at specified wavelengths to assess apoptotic and nonviable cells. The combination would introduce a cost-effective treatment which may induce more apoptosis than current chemotherapy, thus decreasing the typical hardships in cancer treatment today. After experimentation, it was shown that because t(14)=1.7613, p