Exploring the Role of Circulating MIR-134 In Breast Cancer Recurrence
School Name
Dutch Fork High School
Grade Level
11th Grade
Presentation Topic
Cell and Molecular Biology
Presentation Type
Mentored
Oral Presentation Award
2nd Place
Abstract
MicroRNAs (miRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the regulation of gene expression. My previous study has identified the serum miR-134 as a new biomarkers to predict breast cancer recurrence after primary treatment. To further study the function of miR-134 in breast cancer progression, I transfected miR-134 into breast cancer and macrophage cells. I found that overexpression of miR-134 had no effect on tumor cell proliferation but induced macrophage phenotypic changes. Interestingly, the conditioned medium from miR-134 overexpressed macrophage cells promoted the growth of tumor cells. My results suggested that circulating miR-134 may promote tumor progression and recurrence by potentially mediating the interaction between tumor cells and immune cells.
Recommended Citation
Chen, Lauren, "Exploring the Role of Circulating MIR-134 In Breast Cancer Recurrence" (2019). South Carolina Junior Academy of Science. 98.
https://scholarexchange.furman.edu/scjas/2019/all/98
Location
Founders Hall 114 A
Start Date
3-30-2019 2:00 PM
Presentation Format
Oral and Written
Group Project
No
Exploring the Role of Circulating MIR-134 In Breast Cancer Recurrence
Founders Hall 114 A
MicroRNAs (miRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the regulation of gene expression. My previous study has identified the serum miR-134 as a new biomarkers to predict breast cancer recurrence after primary treatment. To further study the function of miR-134 in breast cancer progression, I transfected miR-134 into breast cancer and macrophage cells. I found that overexpression of miR-134 had no effect on tumor cell proliferation but induced macrophage phenotypic changes. Interestingly, the conditioned medium from miR-134 overexpressed macrophage cells promoted the growth of tumor cells. My results suggested that circulating miR-134 may promote tumor progression and recurrence by potentially mediating the interaction between tumor cells and immune cells.
