Title

The Effect of Acetylcholinesterase Inhibitors on the Memory Performance of Caenorhabditis elegans

Author(s)

Sarah Suh

School Name

Spring Valley High School

Grade Level

10th Grade

Presentation Topic

Microbiology

Presentation Type

Non-Mentored

Abstract

Alzheimer's Disease and other dementia are ranked in the top five leading causes of death, globally. Dementia is caused by neurodegeneration and neurodegeneration correlates to the low levels of acetylcholine levels. So the purpose of this research is to find out if certain substances that induce the breakdown of acetylcholine has an effect on Caenorhabditis elegans and their memory performing to run through a maze. The C. elegans were designed to run through a double bifurcation T-maze formatted agar agar maze while on the effects of the substances. The differences between the initial time of running through the test and the second tie were found. between the substances, the data were not statistically significant and that between the levels of concentration, it were statistically significant. For the substances, the time differences between each substance resulted with an F-value of 1.37 and a p-value >0.05, so it resulted in failing to reject the null hypothesis of there being no statistical difference between the time differences of each substance. However for the levels of concentration, there was an F-value of 3.33 and a p-value <0.05, so this interpreted as a rejection to the null hypothesis. The mean differences of time for each substance demonstrated a rejection to the hypothesis that as the levels of concentration of each substance increase the time spent of the C. elegans finishing the maze decreased.

Location

Furman Hall 126

Start Date

3-28-2020 10:15 AM

Presentation Format

Oral and Written

Group Project

No

COinS
 
Mar 28th, 10:15 AM

The Effect of Acetylcholinesterase Inhibitors on the Memory Performance of Caenorhabditis elegans

Furman Hall 126

Alzheimer's Disease and other dementia are ranked in the top five leading causes of death, globally. Dementia is caused by neurodegeneration and neurodegeneration correlates to the low levels of acetylcholine levels. So the purpose of this research is to find out if certain substances that induce the breakdown of acetylcholine has an effect on Caenorhabditis elegans and their memory performing to run through a maze. The C. elegans were designed to run through a double bifurcation T-maze formatted agar agar maze while on the effects of the substances. The differences between the initial time of running through the test and the second tie were found. between the substances, the data were not statistically significant and that between the levels of concentration, it were statistically significant. For the substances, the time differences between each substance resulted with an F-value of 1.37 and a p-value >0.05, so it resulted in failing to reject the null hypothesis of there being no statistical difference between the time differences of each substance. However for the levels of concentration, there was an F-value of 3.33 and a p-value <0.05, so this interpreted as a rejection to the null hypothesis. The mean differences of time for each substance demonstrated a rejection to the hypothesis that as the levels of concentration of each substance increase the time spent of the C. elegans finishing the maze decreased.