Title

Synthesis and DNA-Binding Properties of a 4-Hydroxymethylpurrole-Containung Analog of Netropsin

ACS Citation

Preti, C. S.; Simpson, J. E.; Lee, M. Synthesis and DNA-Binding Properties of a 4-Hydroxymethylpurrole-Containung Analog of Netropsin. Med. Chem. Res. 1995, 5, 426-430.

Abstract

A 4-hydroxymethylpyrrole-containing analog 3 of netropsin has been designed and synthesized. Data from an ethidium bromide displacement assay and CD titration studies showed that it has a preference for the minor groove of AT over GC rich sequences.

Source Name

Medicinal Chemistry Research

Publication Date

1-1-1995

Volume

5

Issue

6

Page(s)

601-615

Document Type

Citation

Citation Type

Article