Synthesis and DNA-Binding Properties of a 4-Hydroxymethylpurrole-Containung Analog of Netropsin
ACS Citation
Preti, C. S.; Simpson, J. E.; Lee, M. Synthesis and DNA-Binding Properties of a 4-Hydroxymethylpurrole-Containung Analog of Netropsin. Med. Chem. Res. 1995, 5, 426-430.
Abstract
A 4-hydroxymethylpyrrole-containing analog 3 of netropsin has been designed and synthesized. Data from an ethidium bromide displacement assay and CD titration studies showed that it has a preference for the minor groove of AT over GC rich sequences.
Source Name
Medicinal Chemistry Research
Publication Date
1-1-1995
Volume
5
Issue
6
Page(s)
601-615
Document Type
Citation
Citation Type
Article
COinS