Title

A reversible colorimetric and fluorescent polydiacetylene vesicle sensor platform

ACS Citation

Yuan, Z.; Hanks, T. W. A reversible colorimetric and fluorescent polydiacetylene vesicle sensor platform. Polymer 2008, 49, 5023-5026.

Abstract

A multi-functional liposome has been developed that demonstrates reversible changes in color and fluorescence intensity in response to changes in pH. Addition of a pendant tryptophan moiety gives the assembly the ability to detect Escherichia coli. The sensor platform is made from a polymerized vesicular assembly of hydrazide-terminated diacetylene lipids and a BO558 fluorescent dye. The polymer backbone is responsible for the color change, while the organization induced by hydrogen bonding of the terminal hydrazide groups permits the reversibility of the color change. Fluorescence quenching is due to internal rearrangement of the liposome and occurs in both polymerized and unpolymerized structures.

Source Name

Polymer

Publication Date

1-1-2008

Volume

49

Issue

23

Page(s)

11-22

Document Type

Citation

Citation Type

Article