Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP): An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies
ACS Citation
Lee, M. Determination of the Solution Conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP): An Advanced Chemistry and Biochemistry Project Using NMR and Molecular-Modeling Studies. J. Chem. Educ. 1996, 73, 184-184.
Version of Record
Abstract
The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees. The conformation of 3'-Azido-3'-deoxythymidine-5'-monophosphate (AZTMP) in an aqueous solution buffered at pH 7.2 was determined using a combination of NMR (1H and 31P) and molecular modelling techniques. Under the conditions studied, AZTMP was found to adopt a C1'-exo, primarily beta(t) and gamma(+) conformation with torsional angle -139.9 degrees.
Source Name
Journal of Chemical Education
Publication Date
1-1-1996
Volume
73
Issue
2
Page(s)
363-363
Document Type
Citation
Citation Type
Article