Neighborhood-Aware Variant Impact Predictor (NAVIP)
Department, Center, or Institute
Biology
Presentation Format
Poster
Presentation Type
Off-campus research
Description
Current annotation tools such as ANNOVAR and SnpEff misannotate a very few challenging cases such as when Indels cause frameshifts or compensate one another, causing it to not show the full mutation. Neighborhood-Aware Variant Impact Predictor (NAVIP) is a program intended to fix these problems by identifying these regions and correctly labeling them. This project tests the effectiveness of NAVIP and investigates co-occuring varients where the original amino acid is preserved from the second mutation. We identify multiple occurrences of the co-occuring varients in Arabidopsis thaliana and discuss the possible reasons for these. This work was performed at Bielefeld University, Center for Biotechnology, Germany.
Session Number
5
Start Date and Time
4-9-2019 4:00 PM
Location
PAC Gym
Recommended Citation
Howard, Dakota, "Neighborhood-Aware Variant Impact Predictor (NAVIP)" (2019). Furman Engaged!. 323.
https://scholarexchange.furman.edu/furmanengaged/2019/all/323
Neighborhood-Aware Variant Impact Predictor (NAVIP)
PAC Gym
Current annotation tools such as ANNOVAR and SnpEff misannotate a very few challenging cases such as when Indels cause frameshifts or compensate one another, causing it to not show the full mutation. Neighborhood-Aware Variant Impact Predictor (NAVIP) is a program intended to fix these problems by identifying these regions and correctly labeling them. This project tests the effectiveness of NAVIP and investigates co-occuring varients where the original amino acid is preserved from the second mutation. We identify multiple occurrences of the co-occuring varients in Arabidopsis thaliana and discuss the possible reasons for these. This work was performed at Bielefeld University, Center for Biotechnology, Germany.