Title
Diet-Induced Neuroinflammation: Microgliosis Due to Binge Eating
Department, Center, or Institute
Psychology
Secondary Department, Center, or Institute
Neuroscience
Presentation Format
Department Organized Oral Session
Presentation Type
On-campus research
Description
Microglia are the resident immune cells of the central nervous system (CNS). In the basal state, microglia exhibit ramified morphology and are often characterized by numerous, long dynamic processes that serve as constant surveillance within the neural parenchyma. Persistent and prolonged activation of microglia has been observed in several neurodegenerative diseases and has been identified as a potential cause of neural dysfunction. In addition, previous research has demonstrated that consumption of a high fat diet can lead to obesity and several neurodegenerative diseases.A potential cause of diet-induced cognitive impairment is microglial inflammation. There are complex interactions between food intake and microglial activation that have not yet been studied in depth. In the present study, we evaluated microgliosis in the cortex, hippocampus, and hypothalamus for female Sprague Dawley rats fed a high fat diet on an intermittent access schedule (binge eating). Our initial qualitative data reveals differences in microglial activation in the cortex, hippocampus, and hypothalamus for binge eating female rats fed a high fat diet.
Department Organized Oral Session Title
Neuroscience Program Talks Session III
Moderator/Professor
Erin Wamsley, Psychology and Neuroscience
Session Number
3
Start Date and Time
4-9-2019 1:45 PM
Location
Johns Hall 208
Recommended Citation
Saxena, Juhi and Saxena, Anju, "Diet-Induced Neuroinflammation: Microgliosis Due to Binge Eating" (2019). Furman Engaged!. 481.
https://scholarexchange.furman.edu/furmanengaged/2019/all/481
Diet-Induced Neuroinflammation: Microgliosis Due to Binge Eating
Johns Hall 208
Microglia are the resident immune cells of the central nervous system (CNS). In the basal state, microglia exhibit ramified morphology and are often characterized by numerous, long dynamic processes that serve as constant surveillance within the neural parenchyma. Persistent and prolonged activation of microglia has been observed in several neurodegenerative diseases and has been identified as a potential cause of neural dysfunction. In addition, previous research has demonstrated that consumption of a high fat diet can lead to obesity and several neurodegenerative diseases.A potential cause of diet-induced cognitive impairment is microglial inflammation. There are complex interactions between food intake and microglial activation that have not yet been studied in depth. In the present study, we evaluated microgliosis in the cortex, hippocampus, and hypothalamus for female Sprague Dawley rats fed a high fat diet on an intermittent access schedule (binge eating). Our initial qualitative data reveals differences in microglial activation in the cortex, hippocampus, and hypothalamus for binge eating female rats fed a high fat diet.