Synthesis of the building blocks of life through a glyoxylate-based protometabolism

Department, Center, or Institute

Chemistry

Presentation Format

Department Organized Oral Session

Presentation Type

On-campus research

Description

The aldol addition of glyxoylate to pyruvate or oxaloacetate in water at neutral pH initiates a cycle of reactions that replicates a primitive oxidative metabolism to generate metabolic intermediates and polymer building blocks found in modern biology. In addition to its role in the abiotic supply of complex organics, the reaction pathway may have served as a template for the modern citric acid cycle.

Department Organized Oral Session Title

Undergraduate Chemistry Research

Moderator/Professor

Timothy Hanks, Chemistry

Session Number

3

Start Date and Time

4-9-2019 1:45 PM

Location

Patrick Lecture Room, Plyler Hall 126

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Apr 9th, 1:45 PM

Synthesis of the building blocks of life through a glyoxylate-based protometabolism

Patrick Lecture Room, Plyler Hall 126

The aldol addition of glyxoylate to pyruvate or oxaloacetate in water at neutral pH initiates a cycle of reactions that replicates a primitive oxidative metabolism to generate metabolic intermediates and polymer building blocks found in modern biology. In addition to its role in the abiotic supply of complex organics, the reaction pathway may have served as a template for the modern citric acid cycle.