Design And Synthesis Of A Novel Lsd-1 Inhibitor As A Potential Anti-Tumor Agent
School Name
Governor's School for Science and Math
Grade Level
12th Grade
Presentation Topic
Biochemistry
Presentation Type
Mentored
Oral Presentation Award
2nd Place
Abstract
Compound C1 successfully occupies the enzyme pocket of Lysine-specific demethylase (LSD1) and prevents the demethylation of histone tails. Histone demethylase causes tumor suppressor genes to be turned off. For this reason, LSD1 inhibitors show potential as antitumor agents. Many of the currently known LSD1 inhibitors are poor drug candidates. The purpose of this study was to create a derivative of a known LSD1 inhibitor that is both more active than the original and soluble in water. These properties will allow the compound to be used for tumor-suppressing drugs.
Recommended Citation
Davenport, Frances, "Design And Synthesis Of A Novel Lsd-1 Inhibitor As A Potential Anti-Tumor Agent" (2016). South Carolina Junior Academy of Science. 10.
https://scholarexchange.furman.edu/scjas/2016/all/10
Location
Owens 203
Start Date
4-16-2016 9:45 AM
Design And Synthesis Of A Novel Lsd-1 Inhibitor As A Potential Anti-Tumor Agent
Owens 203
Compound C1 successfully occupies the enzyme pocket of Lysine-specific demethylase (LSD1) and prevents the demethylation of histone tails. Histone demethylase causes tumor suppressor genes to be turned off. For this reason, LSD1 inhibitors show potential as antitumor agents. Many of the currently known LSD1 inhibitors are poor drug candidates. The purpose of this study was to create a derivative of a known LSD1 inhibitor that is both more active than the original and soluble in water. These properties will allow the compound to be used for tumor-suppressing drugs.
Mentor
Mentor: Dr. Woster; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina