Alda-1 Attenuates Hepatic Ischemia/Reperfusion Injury

Veronica McLeod

School Name

Governor's School for Science and Math

Grade Level

12th Grade

Presentation Topic

Physiology and Health

Presentation Type

Mentored

Mentor

Mentor: Dr. Zhong; College of Pharmacy, Medical University of South Carolina Advisor: Lance Riddle

Abstract

Ischemia/reperfusion (I/R) injury is the tissue damage caused when blood flow returns (reperfusion) after a period of lack of blood flow (ischemia). Oxidative stress occurs during I/R and causes the formation of toxic aldehydes. Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme for degradation of these toxic aldehydes, and Alda-1 is a small molecule that increases the activity of ALDH2. While Alda-1 has been known to reduce different oxidative stress-related diseases such as radiation dermatitis and I/R in the heart and brain, its effect in the liver is unknown. We examined the effects of Alda-1 using a mouse warm I/R model (1 hour ischemia to 70% of liver before ischemia).

Location

Owens 107

Start Date

4-16-2016 10:00 AM

COinS
 
Apr 16th, 10:00 AM

Alda-1 Attenuates Hepatic Ischemia/Reperfusion Injury

Owens 107

Ischemia/reperfusion (I/R) injury is the tissue damage caused when blood flow returns (reperfusion) after a period of lack of blood flow (ischemia). Oxidative stress occurs during I/R and causes the formation of toxic aldehydes. Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme for degradation of these toxic aldehydes, and Alda-1 is a small molecule that increases the activity of ALDH2. While Alda-1 has been known to reduce different oxidative stress-related diseases such as radiation dermatitis and I/R in the heart and brain, its effect in the liver is unknown. We examined the effects of Alda-1 using a mouse warm I/R model (1 hour ischemia to 70% of liver before ischemia).