Wrinkled PDMS Substrate for Cardiac Cell Cultures
Abstract
The structure of a heart at the cellular level is very complex and sensitive to the cues provided by the topography or the physical features of the heart. In order to study heart function based off this topography using a cell culture model, it is required that the model should represent the actual heart (in-vivo) structure as close as possible. In this presentation, we report that by mimicking the topographic cues at very small levels (micro- and nano-) using a silicon polymer (PDMS) and a lab-made cell stretcher, we successfully created an in-vivo-like cell-cell contact in a cell culture model using a wrinkled PDMS substrate we fabricated.
Wrinkled PDMS Substrate for Cardiac Cell Cultures
Founders Hall 114 A
The structure of a heart at the cellular level is very complex and sensitive to the cues provided by the topography or the physical features of the heart. In order to study heart function based off this topography using a cell culture model, it is required that the model should represent the actual heart (in-vivo) structure as close as possible. In this presentation, we report that by mimicking the topographic cues at very small levels (micro- and nano-) using a silicon polymer (PDMS) and a lab-made cell stretcher, we successfully created an in-vivo-like cell-cell contact in a cell culture model using a wrinkled PDMS substrate we fabricated.
