The Effect of Cannabidiol on the Oxidative Stress Response of C. elegans
School Name
Spring Valley High School
Grade Level
11th Grade
Presentation Topic
Biochemistry
Presentation Type
Non-Mentored
Abstract
Oxidative stress is an important factor in several health issues including aging, cancer, and neurodegenerative diseases (Rodriguez et al., 2015). Antioxidants are substances that can mitigate oxidative stress and are therefore important for human health. Cannabidiol (CBD) is one such antioxidant as well as a relatively new and popular product on the market, therefore researching its effects is an important endeavor for the sake of public health (Atalay et al., 2019). The purpose of this study is to test the antioxidative qualities of CBD using C. elegans as a model organism and Hydrogen Peroxide (H2O2) to induce oxidative stress. It was hypothesized that the C. elegans populations exposed to both CBD and H2O2 would have a lower mortality rate compared to those exposed to H2O2 due to CBD’s antioxidative properties. The C. elegans were separated into 4 groups (control, H2O2, CBD, and both) with 5 populations each and were all observed over the course of a school day. The findings of the research were inconclusive as no C. elegans died during the observation time period. The reasoning for this is most likely that the H2O2 were far too diluted to cause death in the C. elegans over the observation time period.
Recommended Citation
Papaletsos, Michael, "The Effect of Cannabidiol on the Oxidative Stress Response of C. elegans" (2023). South Carolina Junior Academy of Science. 3.
https://scholarexchange.furman.edu/scjas/2023/all/3
Location
ECL 115
Start Date
3-25-2023 9:30 AM
Presentation Format
Oral and Written
Group Project
No
The Effect of Cannabidiol on the Oxidative Stress Response of C. elegans
ECL 115
Oxidative stress is an important factor in several health issues including aging, cancer, and neurodegenerative diseases (Rodriguez et al., 2015). Antioxidants are substances that can mitigate oxidative stress and are therefore important for human health. Cannabidiol (CBD) is one such antioxidant as well as a relatively new and popular product on the market, therefore researching its effects is an important endeavor for the sake of public health (Atalay et al., 2019). The purpose of this study is to test the antioxidative qualities of CBD using C. elegans as a model organism and Hydrogen Peroxide (H2O2) to induce oxidative stress. It was hypothesized that the C. elegans populations exposed to both CBD and H2O2 would have a lower mortality rate compared to those exposed to H2O2 due to CBD’s antioxidative properties. The C. elegans were separated into 4 groups (control, H2O2, CBD, and both) with 5 populations each and were all observed over the course of a school day. The findings of the research were inconclusive as no C. elegans died during the observation time period. The reasoning for this is most likely that the H2O2 were far too diluted to cause death in the C. elegans over the observation time period.
