Title

The Effect of Cannabidiol on the Oxidative Stress Response of C. elegans

School Name

Spring Valley High School

Grade Level

11th Grade

Presentation Topic

Biochemistry

Presentation Type

Non-Mentored

Abstract

Oxidative stress is an important factor in several health issues including aging, cancer, and neurodegenerative diseases (Rodriguez et al., 2015). Antioxidants are substances that can mitigate oxidative stress and are therefore important for human health. Cannabidiol (CBD) is one such antioxidant as well as a relatively new and popular product on the market, therefore researching its effects is an important endeavor for the sake of public health (Atalay et al., 2019). The purpose of this study is to test the antioxidative qualities of CBD using C. elegans as a model organism and Hydrogen Peroxide (H2O2) to induce oxidative stress. It was hypothesized that the C. elegans populations exposed to both CBD and H2O2 would have a lower mortality rate compared to those exposed to H2O2 due to CBD’s antioxidative properties. The C. elegans were separated into 4 groups (control, H2O2, CBD, and both) with 5 populations each and were all observed over the course of a school day. The findings of the research were inconclusive as no C. elegans died during the observation time period. The reasoning for this is most likely that the H2O2 were far too diluted to cause death in the C. elegans over the observation time period.

Location

ECL 115

Start Date

3-25-2023 9:30 AM

Presentation Format

Oral and Written

Group Project

No

COinS
 
Mar 25th, 9:30 AM

The Effect of Cannabidiol on the Oxidative Stress Response of C. elegans

ECL 115

Oxidative stress is an important factor in several health issues including aging, cancer, and neurodegenerative diseases (Rodriguez et al., 2015). Antioxidants are substances that can mitigate oxidative stress and are therefore important for human health. Cannabidiol (CBD) is one such antioxidant as well as a relatively new and popular product on the market, therefore researching its effects is an important endeavor for the sake of public health (Atalay et al., 2019). The purpose of this study is to test the antioxidative qualities of CBD using C. elegans as a model organism and Hydrogen Peroxide (H2O2) to induce oxidative stress. It was hypothesized that the C. elegans populations exposed to both CBD and H2O2 would have a lower mortality rate compared to those exposed to H2O2 due to CBD’s antioxidative properties. The C. elegans were separated into 4 groups (control, H2O2, CBD, and both) with 5 populations each and were all observed over the course of a school day. The findings of the research were inconclusive as no C. elegans died during the observation time period. The reasoning for this is most likely that the H2O2 were far too diluted to cause death in the C. elegans over the observation time period.