Biospecific Recognition of Tethered Small Molecules Diluted in Self‐Assembled Monolayers
ACS Citation
Shuster, M.J.; Vaish, A.; Szapacs, M.E.; Anderson, M.E.; Weiss, P.S.; Andrews, A.M. Biospecific Recognition of Tethered Small Molecules Diluted in Self-Assembled Monolayers. Advanced Materials.2008,20, 164-167.
Version of Record
Abstract
We describe the first in a series of studies designed to develop and to characterize self‐assembled monolayers containing isolated small‐molecule probes. We insert tether molecules into preformed oligo(ethylene glycol)‐terminated alkanethiolate monolayer matrices and covalently attach the neurotransmitter serotonin to the tethers. These monolayers selectively recognize serotonin antibodies and resist binding of nonspecific antibodies and proteins. We will use these capture materials for biosensor development and functionally‐directed proteomics.
Source Name
Advanced Materials
Publication Date
1-1-2008
Volume
20
Issue
1
Page(s)
164-167
Document Type
Citation
Citation Type
Article